Since the inception of antibiotic therapy, the dramatic healing power of antimicrobial agents has been threatened by the ever more insistent emergence of antibiotic-resistant bacteria. Some of the clinical1 and biologic2 problems posed by this phenomenon have been summarized recently. Until lately, the principal mechanism responsible for drug resistance was thought to be spontaneous mutation at a low rate to a particular drug resistance followed by selection of resistant cells in the presence of the drug.Although threatening enough, this mechanism is slow and cumbersome in comparison with infectious multiple drug resistance, a newly discovered process that is intellectually fascinating . . .
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A 1966 study studied this question.
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