Key result
The C-terminus of TFPI is essential for its binding to lipoproteins, and co-incubation with heparin inhibits this binding in a dose-dependent manner.
Population
In vitro assays (plasma lipoproteins, VLDL/LDL) and in vivo rabbit model
Comparison
Full-length tissue factor pathway inhibitor with… vs C-terminal degraded TFPI
Design
Preclinical
Follow-up
5 minutes (in vivo)
Authors
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Hypothesis-generating for TFPI-lipoprotein modulation; leaves open relevance to human coagulation or heparin effects.
The C-terminus of TFPI is essential for its interaction with lipoproteins, and this binding is competitively inhibited by heparin.
Valentin et al. (1993) studied this question. Full length TFPI vs. C-terminal degraded TFPI was evaluated on Lipoprotein binding. The C-terminus of TFPI is essential for its binding to lipoproteins, and co-incubation with heparin inhibits this binding in a dose-dependent manner.
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