A 52-year-old woman with bullous pemphigoid developed a bizarre figurate erythematous eruption and generalized pigmentation and velvety skin thickening. Later on, these cutaneous signs were found to be associated with an underlying adenocarcinoma of the stomach. Double-diffusion precipitation and indirect immunofluorescence, however, failed to demonstrate circulating antibodies against the tumor tissue in our patient.
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Urano-Suehisa et al. (2009) studied this question.