// HaiYang Wang 1 , Yu-Jin Jo 1 , Jeong Su Oh 2 and Nam-Hyung Kim 1 1 Department of Animal Sciences, Chungbuk National University, Cheongju, Korea 2 Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea Correspondence to: Jeong Su Oh, email: ohjs@skku.edu Nam-Hyung Kim, email: nhkim@chungbuk.ac.kr Keywords: MPF, oocyte, postovulatory aging, quercetin, SIRT Received: November 08, 2016 Accepted: February 20, 2017 Published: March 15, 2017 ABSTRACT If no fertilization occurs at an appropriate time after ovulation, oocyte quality deteriorates rapidly as a process called postovulatory aging. Because the postovulatory aging of oocytes has detrimental effects on embryo development and offspring, many efforts have been made to prevent oocyte aging. Here we showed that quercetin prevented the decline in oocyte quality during postovulatory aging of oocytes. Quercetin treatment reduced aging-induced morphological changes and reactive oxygen species accumulation. Moreover, quercetin attenuated the aging-associated abnormalities in spindle organization and mitochondrial distribution, preventing decrease of SIRT expression and histone methylation. Quercetin also ameliorated the decrease in maturation-promoting factor activity and the onset of apoptosis during postovulatory aging. Furthermore, quercetin treatment during postovulatory aging improves early embryo development. Our results demonstrate that quercetin relieves deterioration in oocyte quality and improves subsequent embryo development.
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