Naloxane and Alcohol Intoxication

Letters and Corrections1 April 1984Naloxane and Alcohol IntoxicationJ. DUCOBU, M.D.J. DUCOBU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-617_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports suggest that naloxone hydrochloride can reverse alcoholic coma (1, 2), whereas at least one paper does not report this effect (3). We report a prospective, double-blinded, randomised, placebo-controlled study of the clinical value of naloxone for reversing ethanol intoxication.We selected 19 consecutive unconscious patients with proven ethanol overdose. Eleven patients had pure ethanol intoxication, and 8 had ethanol and benzodiazepine or barbiturate intoxication. Toxicologic screening was done systematically. When the randomisation code was broken, 10 patients had been treated with 0.8 mg of intravenous naloxone and 8 with placebo. The alcohol values (mean ±...References1. LYONANTONY LJ. Reversal of alcoholic coma by naloxone. Ann Intern Med. 1982;96:464-5. LinkGoogle Scholar2. JEFFREYSVOLANTS DG. An investigation of the role of the specific opioid antagonist naloxone in clinical toxicology. Hum Toxicol. 1983;2:227-31. CrossrefMedlineGoogle Scholar3. NUOTTOPALVALAHDENRAWTA EEU. Naloxone failed to counteract heavy alcohol intoxication [Letter]. Lancet. 1983;2:167. CrossrefMedlineGoogle Scholar4. NABERSOBLEPICKAR DMD. Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatria. 1981;14:160-1. CrossrefMedlineGoogle Scholar5. BADAWYEVANS AM. Naloxone in ethanol intoxication [Letter]. Ann Intern Med. 1983;98:672. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centre Hospitalier de Tivoli 7100 La Louvière Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAmethystic agents influencing toxicodynamics of ethanolÉthanolEthanolPlasma concentrations of β-endorphin, adrenocorticotropic hormone, and cortisol in drinking and abstinent chronic alcoholicsThe effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptidesIntoxicated Airline Pilots: A Case‐based Ethics ModelEthanol-Induced Increase in Endogenous Dopamine Release May Involve Endogenous OpiatesBasic and Clinical Studies on Serotonin, Alcohol, and AlcoholismGastric emptying in the acutely inebriated patientL'intoxication éthylique aiguë dans le Service d'Accueil et d'UrgenceConduite a tenir thérapeutique et surveillanceFocal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis studyPlasma β-endorphin levels in chronic alcoholicsAcute Ethanol Poisoning and the Ethanol Withdrawal SyndromePOSTER COMMUNICATIONS 1 April 1984Volume 100, Issue 4Page: 617-618KeywordsAlcoholicsAlcoholismAlcoholsComaEthanolIntoxication Issue Published: 1 April 1984 PDF DownloadLoading ...