Influence of Irradiation and Hyperthermia on the Wound Healing of the Intestinal Anastomosis and the Skin Suture in Rat.

This is the authors' abstract. We don't add key points for this paper.

The influence of irradiation and/or hyperthermia on the wound healing in the rats was studied. In this study, an exteriorized segment of the small intestine or the skin of the right foot was exposed to single doses of irradiation (15Gy), local hyperthermia (44°C, 30 minutes), or irradiation plus hyperthermia. After the treatment, intestinal anastomosis or skin suture was performed. The wound healing was assessed by the bursting pressure of the anastomosis, by the tensile strength of suture of the skin, by the hydroxyproline concentration of the tissue around the anastomosis or the skin suture. The wound healing was significantly deteriorated in the group of irradiation. On the other hand, there was no difference in wound healing between the group of hyperthermia and the control group. In the group of combined irradiation and hyperthermia, depressed wound healing was observed. However in this group further deterioration of wound healing was not observed comparing to the irradiation group. It was concluded that under the conditions of this experimental model, hyperthermia did not cause any significant deterioration of wound healing of the intestinal anastomosis and the skin suture.