Chlorhexidine acts synergistically with the polymyxins B and E causing increased and rapid release of cell contents from Pseudomonas aeruginosa. While the polymyxin target molecule is phospholipid, evidence is provided for the proposal that the primary target for Chlorhexidine action is a protein component of the cytoplasmic membrane.
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Al-Najjar et al. (1979) studied this question.
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