Key result
The extent of mismatched Q defects in V/Q SPECT/CT showed a significant but weak correlation with preoperative mPAP (rs=0.09474, p=0.0016) and PVR (rs=0.045, p=0.045) in patients with CTEPH.
Why the study?
The study aimed to analyze the correlation between the extent of mismatched Q defects on V/Q SPECT/CT and preoperative clinical and hemodynamic parameters in patients with CTEPH.
Does the extent of mismatched Q defects on V/Q SPECT/CT correlate with hemodynamic parameters in patients with CTEPH?
Observational (n=102)
Does the extent of mismatched Q defects on V/Q SPECT/CT correlate with hemodynamic parameters in patients with CTEPH?
Quantitative assessment of perfusion defects on V/Q SPECT/CT shows a weak but significant correlation with hemodynamic severity (mPAP and PVR) in patients with CTEPH.
Weak correlation limits clinical use of V/Q SPECT/CT for CTEPH hemodynamics; leaves open its value as a noninvasive marker pending validation.
Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with persistent pulmonary vascular obstruction and exercise intolerance, which may benefit from pulmonary endarterectomy (PEA). Ventilation/perfusion (V/Q) scan is the preferred screening test of CTEPH, which can be used to assess the anatomical extent of the disease. This study aimed to analyze the correlation between the extent of mismatched Q defects in V/Q single photon emission computed tomography/computed tomography (SPECT/CT) with preoperative clinical and hemodynamic parameters in patients with CTEPH. Methods: A total of 102 patients with CTEPH prior to PEA having V/Q SPECT/CT scans were retrospectively reviewed. Age, gender, New York Heart Association classification, intraoperative right-sided heart catheterization (mPAP and PVR), and 6-minute walk test (6MWT) findings were obtained from clinical records of patients. Results: Linear regression analysis showed a significant but weak correlation between the preoperative mPAP and PVR with the extent of mismatched Q defects in V/Q SPECT/CT (rs=0.09474 with p=0.0016 and rs=0.045 with p=0.045, respectively). No significant correlation was found between 6MWT and extent of mismatched Q defects in V/Q SPECT/CT (p>0.05). Conclusion: A quantitative assessment of Q defects on V/Q SPECT/CT might provide information about hemodynamic parameters in patients with CTEPH.
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Özgüven et al. (2021) conducted an observational in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=102). Extent of mismatched Q defects in V/Q SPECT/CT was evaluated on Correlation between the extent of mismatched Q defects and preoperative mPAP and PVR (rs=0.09474 for mPAP; rs=0.045 for PVR, p=0.0016 for mPAP; 0.045 for PVR). The extent of mismatched Q defects in V/Q SPECT/CT showed a significant but weak correlation with preoperative mPAP (rs=0.09474, p=0.0016) and PVR (rs=0.045, p=0.045) in patients with CTEPH.
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