Key result
The D/D genotype of the ACE gene I/D polymorphism was significantly associated with a higher prevalence of type 2 diabetes compared to the I/I genotype (8.7% vs 2.8%, RR 3.13).
Why the study?
Does the D allele of the ACE gene I/D polymorphism increase the risk of type 2 diabetes in a Japanese population?
Cross-Sectional (n=902)
No
Does the D allele of the ACE gene I/D polymorphism increase the risk of type 2 diabetes in a Japanese population?
Relative Risk: 3.13 (95% CI 1.31–7.51)
Absolute Event Rate: 8.7% vs 2.8%
p-value: p=0.008
The D allele of the ACE gene I/D polymorphism is an independent risk factor for type 2 diabetes and impaired glucose tolerance in the Japanese population.
D/D genotype association does not support clinical genotyping yet; leaves causal role in type 2 diabetes open for prospective studies.
The association of the ACE gene I/D polymorphism with type 2 diabetes (DM) was examined in a population-based Japanese sample. A total of 902 individuals (490 females and 412 males, age 58.8 +/- 12.2 yr) from a cohort population (n = 3,706) of the Funagata diabetes study were divided into three groups according to genotype: D/D (n = 104), I/D (n = 436) and I/I (n = 362). Chi-square test and ANOVA were used for association studies and to assess the differences in the traits' values, respectively. More individuals with the genotypes D/D and I/D were diabetic (8.7% and 4.1%, respectively) than those with the genotype I/I (2.8%, p = 0.008 and p = 0.032, respectively). The genotype D/D was a risk factor for DM (relative risk (RR) 3.13, 95% CI 1.31-7.51), and also for DM and IGT (RR 1.78, 95% CI 14-2.76). Multiple logistic regression analysis also showed that the genotypes with the D allele were risk factors for DM and IGT even when adjusting for age, sex, hypertension and serum total cholesterol levels (odds ratio 1.49, 95% CI 1.01-2.21). The D allele of the ACE gene I/D polymorphism is a risk factor for DM.
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Daimon et al. (2003) conducted a cross-sectional in Type 2 Diabetes (n=902). ACE gene I/D polymorphism (D/D genotype) vs. I/I genotype was evaluated on Prevalence of Type 2 Diabetes (RR 3.13, 95% CI 1.31-7.51, p=0.008). The D/D genotype of the ACE gene I/D polymorphism was significantly associated with a higher prevalence of type 2 diabetes compared to the I/I genotype (8.7% vs 2.8%, RR 3.13).
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