Temperature‐Induced Size‐Control of Bioactive Surface Patterns

We present a novel method to produce bioactive surface patterns whose size can be changed in response to a variation of the environmental conditions, rather than local treatment. Our approach is based on the structured surface‐immobilization of thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) polymer chains with different transition temperatures. We experimentally demonstrate how the size of an area in which a particular polymer is collapsed or swollen can be controlled by ambient temperature. We show the temperature‐induced size‐control of a bioactive surface pattern by embedding functional motor proteins into the switchable polymer layers.