Hazard Ratio: 0.64 (95% CI 0.3–0.93)
May support initial dual therapy in uncontrolled hypertension; hypothesis-generating for stroke reduction and requires RCT confirmation.
Cardiovascular disease is the leading cause of morbidity and mortality globally, as the result of a high prevalence of cardiovascular risk factors and a failure to control them (1-4). Hypertension is considered the most important cardiovascular risk factor because of its very high prevalence, with at least 1 billion adults affected worldwide (2), and the direct and linear relationship between blood pressure and cardiovascular events (5). Hypertension is associated with an estimated 9.4 million deaths every year; it is responsible for at least 45% of deaths due to heart disease, and 51% of deaths due to stroke worldwide (1,2).
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Jean Jacques Noubiap (2015) conducted an editorial in Hypertension (n=37,608). Initial dual combination antihypertensive therapy vs. Initial monotherapy was evaluated on Incidence of stroke at 6 months (HR 0.64, 95% CI 0.30-0.93).
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