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The influence of oral or intravenous administration of Δ1-hydrocortisone on plasma 17-OHCS concentrations was studied. With comparable oral doses Δ1-hydrocortisone produced 17-OHCS elevations of greater magnitude and longer duration than did hydrocortisone. Also, the half-life of the Δ1-steroid was longer than that of hydrocortisone. It was concluded that a slower metabolism of the Δ1 form occurs and postulated that this might contribute to the greater clinical effectiveness of this steroid.
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Ely et al. (1956) studied this question.
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