X-Ray structural data for a,b-h,g-[Pt{o-C6H4C(Me)NOC(O)Me}(μ-Cl)]2 and ab initio quantum chemical calculations were used to show that the biomimetic hydrolysis of esters and amides within the coordination sphere of a square-planar complex, in general, and the deacylation of cyclometallated aryl oxime esters, in particular, is due to the stereochemical control which arises from the close proximity of the coordinated OH or H2O ligand and the carbonyl carbon (O···C separation 3.47 Å) in the reactive complex [Pt{o-C6H4C(Me)NOC(O)Me}py(OH)] generated in aqueous solution.
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Kazankov et al. (1997) studied this question.
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