Key result
Genetically predicted levels of five common circulating lipids, including LDL (OR 0.998), showed no statistically significant causal relationship with the risk of deep venous thrombosis.
Why the study?
There is current debate in clinical studies regarding the relationship between circulating lipids and deep venous thrombosis.
Do genetically predicted circulating lipids affect the risk of deep venous thrombosis in individuals of European origin?
Observational (n=337,159)
Yes
Do genetically predicted circulating lipids affect the risk of deep venous thrombosis in individuals of European origin?
Genetically predicted levels of five common circulating lipids (APOA1, APOB, LDL, HDL, TGs) do not have a causal effect on the risk of deep venous thrombosis, challenging some previous observational findings.
No lipid modification indicated for DVT prevention; challenges prior observational links and leaves causal effects open.
In view of the current debate about the relationship between lipids and deep venous thrombosis (DVT) in clinical studies, a two-sample Mendelian randomization (MR) study was conducted to clarify the effects of five circulating lipids (apolipoprotein A1, apolipoprotein B, low-density lipoprotein, high-density lipoprotein and triglycerides) on DVT from the perspective of genetic inheritance. Five lipids (exposure) were analysed by MR with DVT (outcome) from two different data sources. For the analysis, we used inverse variance weighting and a weighted mode, weighted median, simple mode and MR-Egger regression to analyse the effect of circulating lipids on DVT. In addition, we used the MR-Egger intercept test, Cochran's Q test and "leave-one-out" sensitivity analysis to evaluate horizontal multiplicity, heterogeneity and stability, respectively, in the analysis. In the analysis, the two-sample Mendelian randomization analysis of five common circulating lipids and DVT showed that common circulating lipids had no causal effect on DVT, which is somewhat inconsistent with the findings of many published observational studies. Based on our results, our two-sample MR analysis failed to detect a statistically significant causal relationship between five common circulating lipids and DVT.
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Luo et al. (2023) conducted an observational in Deep venous thrombosis (n=337,159). Genetically predicted circulating lipids (APOA1, APOB, LDL, HDL, TGs) vs. Lower genetically predicted lipid levels was evaluated on Risk of deep venous thrombosis (LDL representative) (OR 0.998, 95% CI 0.995-1.001, p=0.117). Genetically predicted levels of five common circulating lipids, including LDL (OR 0.998), showed no statistically significant causal relationship with the risk of deep venous thrombosis.
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