The influence of incompatibility for HLA, the MHC in man, on the survival of renal allografts has been clearly demonstrated, and this effect is strongest for HLA-DR matching. The effect is also probably still apparent in the cyclosporine era. However vascularised cardiac allograft models in the mouse can be used to demonstrate that minor histocompatibility antigens may strongly influence graft survival, especially in the presence of H-2 compatibility. Furthermore the response to the allograft can be shown to be genetically controlled, and this is both H-2 and non-H-2 associated. Thus the immune response to an organ allograft in man is likely to be determined by much more complex interactions than merely incompatibility for HLA between donor and recipient.
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Morris et al. (1987) studied this question.