D-Penicillamine-Induced Myasthenia Gravis in Rheumatoid Arthritis

Brief Reports1 November 1977D-Penicillamine-Induced Myasthenia Gravis in Rheumatoid ArthritisROBERT A. GORDON, M.D., JOHN W. BURNSIDE, M.D., F.A.C.P.ROBERT A. GORDON, M.D.Search for more papers by this author, JOHN W. BURNSIDE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-578 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptD-penicillamine is used for the treatment of active rheumatoid arthritis, Wilson's Disease, and cystinuria. It has been reported to be implicated as a cause of autoimmune diseases and serologic autoantibodies. Clinical pictures indistinguishable from lupus erythematosus (1), Goodpasture's syndrome (2), and polymyositis (3) have been reported as complications of D-penicillamine therapy. A reversible form of myasthenia gravis has been reported in England to be associated with the use of D-penicillamine for the treatment of severe rheumatoid arthritis (4) and Wilson's Disease (5). This report describes the case of a patient who developed myasthenia gravis while being treated with D-penicillamine for...References1. CROUZETCAMUSLECAGUILLIENLIÈVRE JJAPJ: Lupus induced by D-penicillamine during the treatment of rheumatoid arthritis. Ann Med Interne (Paris) 125:71-79, 1974 MedlineGoogle Scholar2. STERNLIEBBENNETTSCHEINBERG IBI: D-penicillamine-induced Goodpasture's Syndrome in Wilson's Disease. Ann Intern Med 82:673-675, 1975 LinkGoogle Scholar3. CUCHERGOLDMAN BA: D-penicillamine-induced polymyositis in rheumatoid arthritis. Ann Intern Med 85:615-616, 1976 LinkGoogle Scholar4. BUCKNALLDIXONGLICKWOODWARDZUTSHI RAEJD: Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis. Br Med J 1:600-603, 1975 CrossrefMedlineGoogle Scholar5. CZLONKOWSKA A: Myasthenia syndrome during penicillamine treatment. Br Med J 2:726-727, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Division of Internal Medicine The Milton S. Hershey Medical Center The Pennsylvania State University Hershey, PA 17033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnti-MuSK- and anti-AChR-positive myasthenia gravis induced by d-penicillamineAdverse drug reactions to poison antidotesAgents Used to Treat Poisoning with Toxic Metals and Organometallic CompoundsThe crystal and molecular structure of (HgL2)n (L = 4,6-dimethylpyrimidine-2-thiolate)—An unusual helical supramolecular assembly in solid phase: In search of a new antidote to mercury poisoningOcular myasthenia: A protean disorderRheumatic syndromes caused by antirheumatic drugsSouthwestern Internal Medicine Conference: Molecular Mechanisms of Autoimmunityd-Penicillamine-induced myasthenia gravis in primary biliary cirrhosisPrimary biliary cirrhosis and lichen planusPenicillamine-induced myasthenia in rheumatoid arthritis: its clinical and genetic features.Penicillamine: Review and cutaneous manifestationsd-Penicillamine-induced neuromuscular disease in guinea pigsMechanism of lesion production in pemphigus and pemphigoidD-Penicillamine-induced pemphigus syndromeAuto-immune complications of D-penicillamine—a possible result of zinc and magnesium depletion and of pyridoxine inactivation.Experimental modelsPenicillamine-induced myasthenia gravis in progressive systemic sclerosisAdverse Effects of D-Penicillamine in Rheumatoid ArthritisHOWARD B. STEIN, M.D., A. CAROLINE PATTERSON, M.B., ROBERT C. OFFER, M.D., CHRISTOPHER J. ATKINS, M.B., ALVENA TEUFEL, R.N., HAROLD S. ROBINSON, M.D.Penicillamine, its metabolism and therapeutic applications: A reviewEffects of D-penicillamine on neuromuscular transmission in ratsPenicillamine-induced myasthenia gravisHeavy metal antagonistsPtosis and Weakness after Start of D-Penicillamine TherapySTEVEN G. ATCHESON, M.D., JOHN R. WARD, M.D. 1 November 1977Volume 87, Issue 5Page: 578-579KeywordsAutoantibodiesAutoimmune diseasesLupus erythematosusMyasthenia gravisPolymyositisRheumatoid arthritis Issue Published: 1 November 1977 PDF DownloadLoading ...