Elastosis perforans serpiginosa and pseudoxanthoma elasticum-like skin change due to D-penicillamine

High dose D‐penicillamine is used in the therapy of Wilson's disease and cystinuria. Elastosis perforans serpiginosa (Guilaine, Benhamou & Molas, 1972), penicillamine dermopathy (Sternleib & Scheinberg, 1964; Katz, 1967; Beer & Cooke, 1967), cutis hyperelastica (Charlebois, Cadotte & Barbeau, 1972), excessive skin wrinkling (Greer, Askew & Richardson, 1976) and pseudoxanthoma elasticum‐like skin change (Meyrick Thomas et al., 1984) have all been documented as developing in consequence of such therapy. We report a patient in whom mild pseudoxanthoma elasticum‐like skin change and elastosis perforans serpiginosa developed, following high dose D‐penicillamine treatment for cystinuria.