Key result
A novel nomogram incorporating age, smoking status, intraluminal thrombus, patent lumbar arteries, and inferior mesenteric artery characteristics effectively predicted type II endoleak risk after EVAR with an AUC of 0.806.
Why the study?
Type II endoleak is the most common EVAR complication and can cause aneurysm sac expansion and rupture, making the identification of high-risk patients crucial for prophylaxis and early intervention.
Does a nomogram based on clinical and anatomical factors accurately predict the risk of Type II endoleak in patients undergoing EVAR for infrarenal AAA?
Cohort (n=332)
No
Does a nomogram based on clinical and anatomical factors accurately predict the risk of Type II endoleak in patients undergoing EVAR for infrarenal AAA?
A novel nomogram incorporating six clinical and anatomical factors can accurately predict the risk of Type II endoleak after EVAR, aiding in personalized surveillance and early intervention.
Nomogram may aid post-EVAR T2EL risk stratification; leaves open prospective multicenter validation before practice change.
Objective: Type II endoleak (T2EL) is the most common complication following endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAA). T2EL may lead to aneurysm sac expansion and rupture. Identifying high-risk patients is crucial for prophylaxis and early intervention. Methods: This single-center retrospective study included 332 patients who underwent EVAR for infrarenal AAA. Demographic, clinical, anatomical, and medication-related data were collected. A nomogram was developed based on significant predictors. Its performance was assessed by receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Results: T2EL occurred in 70 (21.08%) of 332 patients. Multivariate logistic regression revealed six independent predictors: age, smoking status, intraluminal thrombus (ILT), number of patent lumbar arteries (LA), inferior mesenteric artery (IMA) diameter, and IMA patency. The nomogram demonstrated excellent calibration and strong predictive ability, with an area under the curve (AUC) of 0.806 (training set) and 0.758 (validation set). DCA showed clinical benefit across threshold probabilities of 1%-66% and 79%-92% in the training set, and 1%-84% in the validation set. Conclusion: The proposed nomogram effectively integrates clinical and anatomical factors to assess the risk of T2EL after EVAR. It may help identify patients requiring intensified surveillance or early interventions to mitigate complications. Further multicenter, prospective studies are needed to validate the nomogram's applicability.
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Liu et al. (2025) conducted a cohort in Infrarenal abdominal aortic aneurysm (AAA) (n=332). Nomogram incorporating clinical and anatomical risk factors was evaluated on Prediction of Type II endoleak (T2EL) occurrence within 1 year after treatment (AUC 0.806, 95% CI 0.750-0.855). A novel nomogram incorporating age, smoking status, intraluminal thrombus, patent lumbar arteries, and inferior mesenteric artery characteristics effectively predicted type II endoleak risk after EVAR with an AUC of 0.806.
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