Key result
Comparisons of capsid sequences identified substitutions in neutralising antigenic sites (1, 2 and 4) that underpin the observed antigenic phenotypes of FMDV serotype A viruses.
Identified specific capsid sequence substitutions responsible for antigenic variation and vaccine mismatch in Middle Eastern FMDV serotype A strains.
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May guide FMDV vaccine strain selection; leaves open in vivo validation of cross-protection.
Upadhyaya et al. (2013) studied Foot-and-mouth disease viruses (FMDV) serotype A (n=57). Capsid sequence analysis was evaluated on Antigenic relationship (r1) values and capsid sequence substitutions. Comparisons of capsid sequences identified substitutions in neutralising antigenic sites (1, 2 and 4) that underpin the observed antigenic phenotypes of FMDV serotype A viruses.
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