The addition of hexahomoserine (α-amino-ε-hydroxycaproic acid) to complete rations produces growth inhibition, anemia, and a considerable rise in blood plasma amino nitrogen in the rat. Simultaneous administration of lysine prevents the anemia and partially restores growth but does not affect the amino nitrogen level in the plasma. These effects of hexahomoserine and the antagonistic action of lysine are even more striking in animals previously depleted of lysine. Aminoadipic acid cannot replace lysine in the ration and it produces anemia in lysine-depleted rats. Its action is also counteracted by lysine. Liver concentrates and folic acid are ineffective in the prevention of the anemia caused by hexahomoserine.
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Pagé et al. (1949) studied this question.