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Aqueous extracts of three species used in Brazilian popular medicine (Sambacus australis, Bauhnea forficata, Mimosa bimucromata) were screened for the presence of mutagenic activity in the Ames test. The extracts showed frameshift mutagenic activity after metabolization. In addition, M. bimucromata presented positive results in the TA100 strain, which detects a base pair substitution, with and without metabolization. The metabolites of B. forficata extract also showed mutagenic activity in the TA102 strain. The presence of flavonoids and tannins in the extracts may be correlated to positive mutagenic activity.
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Bresolin et al. (1993) studied this question.
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