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Spontaneous mutants of the methane-producing archaebacterium Methanococcus vannielii have been isolated which are resistant to bromoethane-sulphonate, A2315-A (a virginiamycin), neomycin and thiostrepton. Ultraviolet (UV) irradiation followed by growth in bacitracin led to the isolation of bacitracin-resistant mutants. In vitro translation reactions using ribosomes prepared from neomycin or A2315-A-resistant mutants were sensitive to neomycin or A2315-A indicating that the in vivo resistance of the mutants must reflect changes in the permeability of the M. vannielii proteinaceous cell envelope.
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Haas et al. (1986) studied this question.
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