Although the eruption of herpes zoster may appear without discomfort, the pain associated with the condition is some- times considerable; and post-herpetic neuralgia may occur with such severity and persistence that, as Osler (1898) recorded, it has been known to drive a patient to commit suicide. The treatments recommended have been legion, including iron, arsenic, strychnine, gelsemium, valerian, and aconite, as well as the customary analgesics; freezing, liniments, diathermy, and the injection of distilled water beneath the skin have also been used.
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J.F. Galpine (1949) studied this question.