Why the study?
Is the poliomyelitis vaccine safe and effective for routine immunization?
Is the poliomyelitis vaccine safe and effective for routine immunization?
Surveillance data from England and Wales confirmed the safety and efficacy of the poliomyelitis vaccine for routine immunization.
Observational surveillance supports polio vaccine assessment; leaves open causal questions on rare associated cases without randomized data.
When, in 1956, inactivated poliomyelitis (Salk) vaccine became available for routine immunization in England and Wales the Ministry of Health set up a scheme of poliomyelitis surveillance. The objects were to provide a means of rapid detection pf pos sible outbreaks of vaccine-induced poliomyelitis, such as occurred in the United States owing to the presence of incompletely inactivated virus in a batch of vaccine (Nathanson and Langmuir, 1963), and to observe the efficacy of the vaccine. The results were reported by Geffen and Spicer (1960), Geffen (1960), and Roden (1964), and though a number of vaccine associated cases occurred they concluded that the vaccine was both safe and effective.
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Miller et al. (1965) studied this question.
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