Why the study?
Most patients with acute flaccid myelitis do not experience complete spontaneous recovery, and medical therapy has not proven efficacious.
Do upper extremity nerve transfers improve muscle strength and function in children with acute flaccid myelitis and persistent paralysis?
Case Report (n=2)
No
Do upper extremity nerve transfers improve muscle strength and function in children with acute flaccid myelitis and persistent paralysis?
Upper extremity nerve transfers performed within 1 year of symptom onset may provide significant functional recovery in children with acute flaccid myelitis and persistent paralysis.
Nerve transfers may aid refractory AFM paralysis; leaves open efficacy confirmation in prospective trials.
Acute flaccid myelitis (AFM) is a rare, debilitating neurological disease resulting in pure motor deficits in school-aged children. Unfortunately, 90% of patients do not experience complete spontaneous recovery, and medical therapy has not proven efficacious. Herein, we report the course of 2 patients with AFM who underwent upper extremity nerve transfers to treat persistent upper extremity paralysis after failing roughly 6.5 months of conservative treatment. Objective comparisons were made between preoperative and postoperative examinations using the Active Movement Scale and Mallet Classification. Patient 1 underwent transfers of spinal accessory to suprascapular nerve, medial pectoral to axillary nerve, flexor carpi radialis motor fascicle to motor fascicles of the biceps and brachialis musculocutaneous nerve, and anterior interosseous transfer to deep motor branch of the ulnar nerve. Patient 2 underwent transfers of the left spinal accessory to suprascapular nerve and motor nerve of the long head of the triceps to axillary nerve. Both patients experienced significant improvement in muscle strength and ability to complete activities of daily living, with near complete recovery of function. Nerve transfers in the upper extremity within 1 year of symptom onset appear to be beneficial for children with persistent weakness.
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Ramamurthi et al. (2025) conducted a case report in Acute flaccid myelitis with persistent upper extremity paralysis (n=2). Upper extremity nerve transfers vs. Preoperative baseline was evaluated on Muscle strength and shoulder function assessed via Active Movement Scale and Mallet Classification.
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