Facile Synthesis of Leaf‐Like CuO Nanoparticles and Their Application on Glucose Biosensor

An efficient amperometric biosensor based on well‐crystallized leaf‐like CuO nanoparticles for detecting glucose has been proposed. The leaf‐like CuO nanoparticles, synthesized by a simple one‐step hydrothermal method, were characterized by X‐ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscopy (TEM) for the morphology study. Under the optimal condition, the electrochemical behaviour of the leaf‐like CuO nanoparticles modified electrode for detection of glucose exhibited high sensitivity of 246 µA/mM/cm2, short response time (within 5 s), linear dynamic range from 1.0 to 170 µM (R2=0.9995), and low limit of detection (LOD) (S/N=3) of 0.91 µM. The high sensitivity, good reproducibility, stability, and fast amperometric sensing towards oxidation of glucose, make this biosensor promising for future application.