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Human adenovirus vectors hold great promise as “drugs” to treat cancer. They are relatively easy to grow and manipulate, are very well understood, infect dividing and non-dividing cells from a variety of tissues, and do not cause serious disease in adults. Thousands of papers have been published by many academic and industrial groups on the potential use of adenovirus vectors in cancer gene therapy. These vectors fall into two general categories: replication-defective and replication-competent (oncolytic) [1].
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Tóth et al. (2003) studied this question.
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