Key result
Late motor neuron degeneration following poliomyelitis was characterized by neurogenic alterations on muscle biopsy in all 5 cases, with mitochondrial abnormalities present in 1 case.
Case Report (n=5)
Muscle biopsy in patients with late motor neuron degeneration following poliomyelitis shows neurogenic alterations in both previously and newly affected limbs, with occasional mitochondrial abnormalities.
Supports biopsy characterization of post-polio motor neuron disease; leaves open mitochondrial contribution and generalizability beyond this small series.
5 cases of late motor neuron degeneration following poliomyelitis are presented. CPK, CSF, EMG and spine radiology were studied. In all cases, muscle biopsy evidenced neurogenic alterations both in previously affected limbs and in newly affected ones. Mitochondrial abnormalities were found in 1 case. The findings are discussed in the light of the literature with particular regard to the pathogenesis of the disease. The case with abnormal mitochondria is stressed for the possible relationship of this pathology with systemic degenerative diseases.
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Palmucci et al. (2008) conducted a case report in Late motor neuron degeneration following poliomyelitis (n=5). Poliomyelitis was evaluated on Neurogenic alterations on muscle biopsy. Late motor neuron degeneration following poliomyelitis was characterized by neurogenic alterations on muscle biopsy in all 5 cases, with mitochondrial abnormalities present in 1 case.
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