Gestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia

OBJECTIVE: We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia. METHODS: A retrospective cohort study was performed among 26,105 women. RESULTS: Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83). CONCLUSION: Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.