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Several salicylate derivatives were attached to low molecular weight polyethylene oxides through an ether or carbonate linkage utilizing the respective halide or chlorocarbonate derivative of the polymers as reactive intermediates. Aspirin and 0‐salicoyl salicylic acid were attached to polyvinyl alcohol and cellulose acetate by ester linkage through melt esterification of the reactants. Preliminary pharmacological evaluation of some of the polymeric salicylates showed that they have a longer duration of antiinflammatory and analgesic activities as compared with aspirin.
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Weiner et al. (1974) studied this question.
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