Why the study?
Do phenothiazines cause abnormal electrocardiograms in schizophrenic patients?
Do phenothiazines cause abnormal electrocardiograms in schizophrenic patients?
Phenothiazines are associated with reversible electrocardiographic abnormalities, including Q-T prolongation and repolarization changes, in a significant proportion of patients.
Phenothiazines were associated with reversible ECG abnormalities in schizophrenia; hypothesis-generating and should not yet change practice.
Summary Fifty-nine (42%) of 140 schizophrenic patients taking phenothiazines were found to have abnormal electrocardiograms. The abnormalities included T wave changes, S-T depression, P-R and Q-T prolongation, persistent sinus tachycardia (110 or more/min) and right bundle branch block. In forty-eight (34%) of the fifty-nine patients, the ECG abnormalities disappeared after stopping the phenothiazine and reappeared on its resumption.
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Raj et al. (1975) studied this question.
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