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June 1, 1982Journal of Medicinal Chemistry

Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

Max E. Safdy Elva Kurchacova Robert N. Schut Horacio Vidrio Enrique Hong

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Abstract

A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

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Safdy et al. (1982) studied this question.

synapsesocial.com/papers/6a947281cc4384ea2cc529f3 https://doi.org/10.1021/jm00348a022

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