Evaluating corneal biomechanics using interocular pressure methods and making surrogate models: sensitivity analysis and parametric optimization

The Corvis tonometer is widely used to measure intraocular pressure in the cornea and contact lens. In this study, based on the results of finite element simulations from a previous study, the methodology for gener- ating two types of metamodels is elaborated in detail, and the challenges associated with each is examined. In addition, the sensitivity of each metamodel category to its inputs is analyzed, and the influence of each parameter is thoroughly evaluated. The results show that, even under significant variations in the inputs, the changes in this parameter remain minimal, making it a worthy measure for estimating the projected pressure.