Key result
Integrating in vitro models matched to the specific toxicity studied provides opportunities to address growing challenges in cardio-oncology and probe mechanisms of cardiotoxicity.
Why the study?
Treatment-related cardiovascular disease is a leading cause of morbidity and mortality in cancer survivors, making well-matched in vitro models crucial for investigators studying cardiotoxicity.
This review highlights the importance of appropriately matching in vitro translational models to the specific mechanisms of cardiotoxicity being studied in cardio-oncology.
Answers are grounded in this paper and cite their sources.
Supports tailored in vitro model selection in cardio-oncology research; leaves open clinical translation pending validation.
• Treatment-related cardiovascular disease is a leading cause of morbidity and mortality in cancer survivors. • For investigators, it is crucial that in vitro models are well-matched to the toxicity studied. • From simple to complex, we describe how in vitro models are used to model cardiotoxicity. • Integrating these models will provide opportunities to address growing challenges in cardio-oncology.
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Livingston et al. (2022) conducted a review in Cardiotoxicity. In vitro models was evaluated. Integrating in vitro models matched to the specific toxicity studied provides opportunities to address growing challenges in cardio-oncology and probe mechanisms of cardiotoxicity.
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