Key result
Increased preoperative total serum cholesterol was associated with a 11.2% decrease in endothelium-dependent relaxation per 1 mmol increase in internal mammary arteries (P=0.006).
Why the study?
Do preoperative serum lipid levels correlate with impaired endothelium-dependent relaxation in internal mammary arteries used for coronary bypass surgery?
Observational (n=37)
Do preoperative serum lipid levels correlate with impaired endothelium-dependent relaxation in internal mammary arteries used for coronary bypass surgery?
Effect estimate: 11.2% decrease per 1 mmol increase
p-value: p=0.006
Preoperative total and LDL-cholesterol levels are independent predictors of impaired endothelium-dependent relaxation in internal mammary arteries used for coronary bypass surgery.
May impair IMA endothelial function; hypothesis-generating and requires prospective validation before clinical adoption.
OBJECTIVE: Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. The aim of the present study was to relate preoperative serum lipids to endothelium-dependent relaxation in internal mammary arteries of patients undergoing coronary bypass surgery. METHODS: The study group consisted of 37 patients, from whom segments of the internal mammary artery were obtained during surgery. Measurements of endothelium-dependent relaxation were performed in organ baths by adding methacholine (10 nM-10 microM). RESULTS: All internal mammary arteries dilated in response to methacholine, ranging from 4 to 112% of the precontraction to 10 mumol phenylephrine. In a multiple regression model, increased total serum cholesterol appeared to be the best predictor for impaired endothelium-dependent relaxation. A 1 mmol increase of total cholesterol was associated with a 11.2% decrease of endothelium-dependent relaxation (P = 0.006). When total cholesterol was omitted from the model, LDL-cholesterol became the best predictor of endothelium-dependent relaxation (regression coefficient 10.3%/mmol; P = 0.02). No other variable was significantly associated with endothelium-dependent relaxation, and none of the preoperative variables was associated with endothelium-independent relaxation, expressed as the response to sodium nitrite (10 mM). CONCLUSION: Our study showed that endothelium-dependent relaxation in apparently non-diseased internal mammary arteries used for coronary bypass surgery was independently related to preoperative (LDL)-cholesterol levels.
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Adriaan A. Voors (1997) conducted an observational in Coronary bypass surgery (n=37). Preoperative total serum cholesterol was evaluated on Endothelium-dependent relaxation (11.2% decrease per 1 mmol increase, p=0.006). Increased preoperative total serum cholesterol was associated with a 11.2% decrease in endothelium-dependent relaxation per 1 mmol increase in internal mammary arteries (P=0.006).
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