A novel nontoxic denatured bovine serum albumin (dBSA)-based platform for effectively delivering drugs was prepared. It was demonstrated that the as-prepared dBSA micelles could effectively load and deliver a water insoluble anti-cancer drug in vitro assay. The results also indicated that the denaturization of the BSA did not enhance the cytotoxicity practically, but significantly enhanced its cellular uptake.
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Zhang et al. (2012) studied this question.
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