Key result
An accidental 100 mcg intravenous bolus of dexmedetomidine in a 3-year-old child caused life-threatening bradycardia, hypotension, and miosis, which were successfully treated with an adrenaline infusion.
Case Report (n=1)
No
Adrenaline infusion may be a useful supportive treatment for life-threatening dexmedetomidine toxicity presenting with hemodynamic instability and miosis in pediatric patients.
Adrenaline infusion may support hemodynamics in pediatric dexmedetomidine overdose; hypothesis-generating and requires prospective validation.
We present a case of dexmedetomidine toxicity in a 3-year-old child. The case report describes the features and outlines the treatment strategy adopted. The child presented with bradypnoea, bradycardia, hypotension, deep hypnosis and miosis. He was successfully managed with oxygen, saline boluses and adrenaline infusion. He became haemodynamically stable with adrenaline infusion. He started responding to painful stimuli in 3 h and became oriented in 7 h. Dexmedetomidine, a selective α2 adrenoceptor agonist, is claimed to have a wide safety margin. This case report highlights the fact that dexmedetomidine administered in a toxic dose may be life-threatening may present with miosis and adrenaline infusion may be a useful supportive treatment.
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Nath et al. (2013) conducted a case report in Dexmedetomidine overdose (n=1). Dexmedetomidine overdose was evaluated. An accidental 100 mcg intravenous bolus of dexmedetomidine in a 3-year-old child caused life-threatening bradycardia, hypotension, and miosis, which were successfully treated with an adrenaline infusion.
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