The occurrence of humoral antibodies to Strep. 2A in recurrent aphthous stomatitis (RAS) was investigated by titrating sera and by using a double‐layer immunofluorescence staining method. The series comprised 24 patients with RAS and 24 persons without anamnestic or clinical signs of RAS. The distribution of endpoint titre in RAS differed significantly in relation to the distribution in the controls (p<0.005). No antibodies to a strain of Streptomyces and a strain of Neisseria used were demonstrated in RAS. The results indicate that Strep. 2A hypersensitivity is a feature of RAS.
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Donatsky et al. (1974) studied this question.