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July 1, 1985Antimicrobial Agents and ChemotherapyOpen Access

Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits

Malcolm H. Koldin G S Kobayashi J Brajtburg Gerald Medoff

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Abstract

Amphotericin B was infused into normal rabbits or rabbits made hypercholesterolemic by diet. There was no difference in amphotericin B-induced toxicity between these two groups. Amphotericin B given in a mixture with human low-density lipoproteins was more toxic than when given without lipoproteins.

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Koldin et al. (1985) studied this question.

synapsesocial.com/papers/6a9477e17779db04076e5b49 https://doi.org/10.1128/aac.28.1.144

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