Influence of Temperature on the Biosynthesis of Iron Transport Compounds by Salmonella typhimurium

The biosynthesis of phenolate iron transport compounds by Salmonella typhimurium Tm-1 is temperature-sensitive. As the temperature of incubation is raised from 31.0 to 36.9 C, the organism excretes less iron transport compound into the medium. The organism in unable to grow at 40.3 C on a 1% succinatesalts medium unless supplemented with such iron transport compounds. The iron requirement for maximum cell yields on this medium is 0.10 mug/ml. The biosynthesis of phenolate iron transport compounds is suppressed at iron concentrations greater than 3.0 mug/ml.