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After initial death of most donor lymphocytes in AKR thymus grafts in normal (AKRXT6)F1 mice, there was a temporary period during which active proliferation of surviving donor lymphocytes occurred. This population of dividing lymphocytes in the thymus grafts was subsequently completely replaced by host-type cells. The results suggest that thymic lymphoid stem cells are continuously replaced by cells entering the thymus from the circulation.
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Metcalf et al. (1964) studied this question.
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