After whole-body irradiation with 250 or 350 r, a persistent lymphocytosis develops in C57Bl mice, subsequent to the initial lymphopenia. Serum assays of irradiated mice showing this lymphocytosis reveal elevated levels of the thymic lymphocytosis stimulating factor (LSF). Irradiated mice do not develop a lymphocytosis in response to either trauma or the injection of LSF. Thymectomy, either before or after irradiation, allows normal responsiveness of irradiated mice to LSF.
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D Metcalf (1959) studied this question.
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