Why the study?
Breast adipose tissue is an important contributor to the obesity-breast cancer link, but the role of adipose-derived extracellular vesicles in modulating tumor cell function is not fully understood.
Population
Breast cancer cells and extracellular vesicles from breast adipose tissue of overweight or obese women
Comparison
EVs from overweight or obese women vs EVs from lean women
Design
Preclinical in vitro study
Key result
Extracellular vesicles from breast adipose tissue of overweight or obese women increased breast cancer cell proliferation and mitochondrial respiration via the Akt/mTOR/P70S6K pathway.
Authors
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O-EVs promote breast cancer cell proliferation in vitro; hypothesis-generating for EV roles in obesity-breast cancer progression.
Extracellular vesicles from breast adipose tissue of obese women promote breast cancer cell proliferation and mitochondrial respiration via the Akt/mTOR/P70S6K pathway.
Liu et al. (2023) studied Breast cancer and obesity. Extracellular vesicles from breast adipose tissue of overweight or obese women (O-EVs) vs. Extracellular vesicles from lean women was evaluated on Tumor cell proliferation and mitochondrial respiration. Extracellular vesicles from breast adipose tissue of overweight or obese women increased breast cancer cell proliferation and mitochondrial respiration via the Akt/mTOR/P70S6K pathway.