Key result
Monovalent oral poliovirus vaccines were historically abandoned in favor of the trivalent combination to simplify immunization schedules, without formal efficacy comparisons.
This editorial discusses the historical context and utility of monovalent versus trivalent oral poliovirus vaccines in the global polio eradication campaign.
The polio eradication campaign initiated in 1988 by the World Health Organization (WHO) led to an impressive decline in cases of paralytic poliomyelitis around the world. The eradication strategy involved highly organized mass immunization campaigns, relying solely on the trivalent oral polio vaccine developed by Albert Sabin and licensed in the United States in 1963. Monovalent versions of oral polio vaccine had been licensed earlier but were abandoned in favor of the trivalent combination oral polio vaccine to simplify immunization schedules. Efficacy was not considered to be a significant issue, and differences between monovalent and trivalent vaccines were never formally . . .
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Ehrenfeld et al. (2008) conducted an editorial in Poliomyelitis. Monovalent oral poliovirus vaccines vs. Trivalent oral polio vaccine was evaluated. Monovalent oral poliovirus vaccines were historically abandoned in favor of the trivalent combination to simplify immunization schedules, without formal efficacy comparisons.
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