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Clinical report reveals chronic upper airway obstruction contributes to precocious pulmonary hypertension in Down syndrome, suggesting airway management may mitigate vascular complications.
• Precocious pulmonary hypertension in children with Down's syndrome may occur in patients with or without congenital heart disease. Chronic upper airway obstruction, which is common in Down's syndrome, is a well-recognized stimulus of elevated pulmonary artery pressure and may explain the propensity for idiopathic pulmonary hypertension or accelerated pulmonary vascular changes with left-to-right shunts in these children. (Am J Dis Child1981;135:1050-1052)
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Thomas Rowland (1981) studied this question.
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