Pulse Therapy in Rheumatoid Arthritis

Editorial Notes1 January 1981Pulse Therapy in Rheumatoid ArthritisEVELYN V. HESS, M.D., PAMELA L. KAMMEN, M.D.EVELYN V. HESS, M.D.Search for more papers by this author, PAMELA L. KAMMEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic symptomatic diseases for which specific causes are not known and therefore for which we have no specific therapies are unfortunately still very much with us. This lack has resulted in the use of many forms of therapy that might offer a possibility of improving the quality or extent of life despite the absence of scientific evidence of efficacy and safety. This trend has resulted in use of a variety of medical fads that have fallen by the wayside. The use of high-dose oral steroids in the treatment of rheumatoid arthritis during the 1950s is a well-known example. The consequences...References1. LIEBLINGLIEBMCLAUGHLIN MEK. Pulse methylprednisolone in rheumaotid arthritis: a double-blind cross-over trial. Ann Intern Med. 1981;94:21-6. LinkGoogle Scholar2. KOUNTZCOHN SR. Initial treatment of renal allografts with large intrarenal doses of immunosuppressive drugs. Lancet. 1969;1:338-40. CrossrefMedlineGoogle Scholar3. TURCOTTEFEDUSKACARPENTERMCDONALDBACON JNEFG. Rejection crises in human renal transplant recipients. Arch Surg. 1972;105:230-6. CrossrefMedlineGoogle Scholar4. BELLCALMANWOOD PKR. Reversal of acute clinical and experimental organ rejection using large doses of intravenous prednisolone. Lancet. 1971;1:876-80. CrossrefMedlineGoogle Scholar5. GRAYDAARSHEPHERDOLIVERMORRIS DAHDP. Oral versus intravenous high dose steroid treatment of renal allograft rejection. Lancet. 1978;1:117-8. CrossrefMedlineGoogle Scholar6. VINEYARDFADEMDMOCHOWSKICARPENTERWILSON GSJCR. Evaluation of corticosteroid therapy for acute renal allograft rejection. Surg Gynecol Obstet. 1974;138:225-9. MedlineGoogle Scholar7. FANYUCLEMENTSFOWLSTONEISMANBLUESTONE PDPSJR. Effect or corticosteroids on the human immune response: comparison of the one and three daily 1 gm intravenous pulses of methylprednisolone. J Lab Clin Med. 1978;91:625-34. MedlineGoogle Scholar8. CATHCARTIDELSONSCHEINBERGCOUSER EBMW. Beneficial effects of methylprednisolone "pulse" therapy in diffuse proliferative lupus nephritis. Lancet. 1976;1:163-6. CrossrefMedlineGoogle Scholar9. KIMBERLYLOCKSHINSHERMANMCDOUGALINMANCHRISTIAN RMRJRC. Clinical efficacy of high dose intravenous methylprednisolone pulse therapy of SLE. Arthritis Rheum. 1979;22:629. Abstract. Google Scholar10. FESSEL W. Megadose corticosteroid therapy in SLE. J Rheumatol. 1980;7:486-500. MedlineGoogle Scholar11. LIEBLINGMCLAUGHLINBOONSUEKASDENBARNETT MKSJE. A double-blind placebo controlled trial of pulse-methylprednisolone in SLE nephritis. Arthritis Rheum. 1980;23:711. Abstract. Google Scholar12. DETORRENTEPOPOVTZERGUGGENHEIMSCHRIER AMSR. Serious pulmonary hemorrhage, glomerulonephritis, and massive steroid therapy. Ann Intern Med. 1975;83:218-9. LinkGoogle Scholar13. NEILDLA GH. Methylprednisolone pulse therapy in the treatment of polyarteritis nodosa. Postgrad Med J. 1977;53:382-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Immunology Department of Medicine University of Cincinnati Medical Center Cincinnati, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRheumatic DisordersSystemische und lokale Corticosteroid-Therapie — aus rheumatologischer SichtA randomized, double-blind trial comparing a pulse of 1000 with 250 mg methylprednisolone in rheumatoid arthritisThe use of corticosteroid agents in connective tissue disorders ∗Therapy for immunologic diseaseIntermediate-dose intramuscular methylprednisolone acetate in the treatment of rheumatic disease.Drug Information Analysis ServiceoNitrogen mustard in severe rheumatoid arthritisIntermittent megadose corticosteroid therapy for generalized lichen planusSudden Death After Methylprednisolone Pulse TherapyTOMAS S. BOCANEGRA, M.D., M. OSWALDO CASTANEDA, M.D., LUIS R. ESPINOZA, M.D., FRANK B. VASEY, M.D., BERNARD F. GERMAIN, M.D. 1 January 1981Volume 94, Issue 1Page: 128-129KeywordsArthritisFellowshipsHeart rateRheumatoid arthritisSafetySteroids Issue Published: 1 January 1981 PDF DownloadLoading ...