Anti-inflammatory Action of Vitamin B1 and its Derivatives. I

Anti-inflammatory action of vitamin B1 and its derivatives was examined by three methods : (1) Rat hind paw edema, (2) intraperitoneal dye leakage of the mouse, and (3) vascular permeability of the guinea pig skin. Rat hind paw edema induced by a-chymotrypsin was inhibited by vitamin B1, T.T.F.D. and T.A.T.D. inhibited rat paw edema induced by acetic acid and a-chymotrypsin. B.T.M.P. and S.T.M.P. were effective in the rat paw edema induced by carrageenin. The leakage of dye into the peritoneal cavity in the mouse was inhibited by vitamin B1 and its derivatives except S.T.M.P. when acetic acid was an irritant. They showed significant inhibition of the increase in vascular permeability of the guinea pig skin induced by acetic acid. From these results, it is concluded that when inflammation is induced by acetic acid, vitamin B1 and its derivatives are effective with all the three methods used here. In addition, it was found that the anti-inflammatory action of vitamin B1 derivatives can be divided into two proto-types : (a) T.T.F.D. and T.A.T.D. of disulfide type, (b) B.T.M.P. and S.T.M.P. of S-acyl type.