Further Experimental Evaluation of Two New Corticosteroids

Scientific research and clinical analysis of the newer adrenal corticosteroids are continuously being carried on to evaluate their ability to suppress inflammation, edema, and allergic reaction, with a minimum of side reactions. These research efforts have resulted in improved topical and systemic cortical steroids that provide higher therapeutic effect with low dosage and a minimum amount of side-effects. The analogues, triamcinolone, prednisone, and prednisolone, were found to be superior to cortisone and hydrocortisone.1-5Experimental studies on uveitis revealed that a given anti-inflammatory response required doses several times greater of cortisone and hydrocortisone than triamcinolone-free alcohol, prednisone, or prednisolone.1,4,5 The most recent forms of adrenal steroids are triamcinolone (Aristocort) and dexamethasone (Deronil), which have been considered to be the more potent and relatively least toxic of the corticosteroids. Triamcinolone-free alcohol and triamcinolone diacetate are the parent compounds. The three special derivatives of triamcinolone-free alcohol are triamcinolone acetonide, triamcinolone acetonide