Animal study demonstrates sodium hydrosulfide alleviates neuropathic pain hypersensitivity in mice, suggesting astrocytic EAAT2 regulation offers a therapeutic target for chronic pain.
The potential role of hydrogen sulfide (H 2 S) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect of intraperitoneal injection of the H 2 S donor sodium hydrosulfide (NaHS) on neuropathic pain. Utilizing the spared nerve injury (SNI) model in mice, the research investigates the role of astrocytes and the excitatory neurotransmitter glutamate in chronic pain. The findings reveal that sodium hydrosulfide (NaHS), an H 2 S donor, effectively enhances the mechanical pain threshold and thermal pain escape latency in SNI mice. The study further demonstrates NaHS’s potential in reducing glutamate levels in the spinal cord and the discharge frequency of neurons in the primary somatosensory cortex hindlimb region (S1HL) brain area, suggesting a novel therapeutic approach for neuropathic pain through the modulation of astrocyte function and EAAT2 expression.
No takes yet. Share an insight, caveat, or question.
Qi et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: