Key result
Cell-based neurorestorative therapy improved neurological function, which remained stable over a 4-year follow-up in a patient with postpoliomyelitis syndrome.
Why the study?
Does cell-based neurorestorative therapy improve neurological function in a patient with postpoliomyelitis syndrome?
Case Report (n=1)
Does cell-based neurorestorative therapy improve neurological function in a patient with postpoliomyelitis syndrome?
Cell-based neurorestorative therapy may be a potential treatment option for postpoliomyelitis syndrome, as demonstrated by sustained neurological improvement in a single case.
May suggest benefit in postpoliomyelitis syndrome; leaves open confirmation in controlled trials.
Postpoliomyelitis syndrome refers to the new neuromuscular symptoms that occur in patients, years after their acute poliomyelitis has stabilized. A 64-year-old Danish man presented with lower limb weakness and severe pain for 2 years and 5 months. He had a history of poliomyelitis affecting his limbs 59 years ago. Physical examination revealed atrophy of muscles of both lower limbs. Electromyography revealed that recruitment of maximal voluntary contraction of muscles was decreased in the affected muscles. He received cell-based neurorestorative therapy during admission, and then, his neurological function improved and remained stable during 4-year follow-up. This case report shows that cell therapy could be a treatment option for postpoliomyelitis syndrome.
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Xi et al. (2016) conducted a case report in postpoliomyelitis syndrome (n=1). cell-based neurorestorative therapy was evaluated on neurological function. Cell-based neurorestorative therapy improved neurological function, which remained stable over a 4-year follow-up in a patient with postpoliomyelitis syndrome.
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